Cellular and Molecular Biotechnologies for Medical Applications (2010-2012)

The Post Doc fellowship Program: "Celluar and Molecular Biotechnologies for Medical Application aims at continuing the training of young PhDs in biology, chemistry, physics medical & pharmaceutical sciences for careers in research.

The advanced training in Medical Biotechnology Research is achieved by:

1. targeted individual research projects;
2. the design, implementation si colaboration in integrated research projects;
3. educational training sessions in advanced and emerging fields of the domain, which are not part of the Graduate or PhD curricula.
4. educational training sessions in research management.

This Program is carried out by a Consortium of 6 institutions with signifficant experience in research education: the Institute of Biochemistry of the Romanian Academy; USAMV Cluj; the Clinical Institute for Digestive Diseases and Hepatic Transplant Fundeni - Bucharest; The Institute of Physics and Material Science Technologies; the University of Medicine and Pharmacy Timisoara; and the Faculty of Chemistry of the University of Bucharest.

In the next 36 month the Program will train 40 young Post Docs, selected by interview in sessions held every 6 months on the following research topics:

1. Genomics, Proteomics, Metabolomics and Bioinformatics;
2. Molecular Cell Biology;
3. Cellular Therapies;
4. Biomaterials, nanostructures and pharmacophores.

The young Post Docs could propose, in consensus with the senior research supervisers of the Consortium, projects in the following research areas: Dezvoltare medicamente antivirale fata de virusului hepatitei B si C - IB Nanostructuri pentru eliberare controlata de medicamente - INCD Laser Physics Sinteza dirijata si screeningul unor compusi cu activitate streso-protectoare - UB

• Module 1: Genomics, Proteomics, Metabolomics si Bioinformatics:
1. Development of Bioinformatics Tools for genomics, proteomics, glicomics etc - IB
2. Molecular modelling of protein structure and interaction with ligands - IB
3. Genomics applications in organ and cellular transplant - Inst Fundeni
4. Desmoplastic reaction and pancreatic cancer progression - Inst Fundeni
5. Metabolomics and molecular markers for taxonomic recognition - USAMV Cluj
6. Molecular markers for food authentification - USAMV Cluj
7. Applied chemometry aplicata for food authentification - USAMV Cluj
8. The structure and function of cellular signalling enzymes - IB
• Module 2: the Molecular Biology of the Cell:
1. The cellular homeostasis of proteins in normal and patological states - IB
2. Molecular mechanisms of ER stress and pancreatic beta cells - IB
3. Unfolded protein accumulation in cancer and hipoxia models - IB
4. The expression of glycosylation products receptors in inflamation and diabet - IB
5. The morfology and intracellular trafic of Hep B & C virus - IB
6. Mesenchimal Stem Cells and tumoral fibroblasts comparative studies - UMF Timisoara
7. Mesenchimal Stem Cell differentiation toward adipocytes - UMF Timisoara
8. The cellular response to abiotic stress in S.cerevisiae - UB
• Module 3: Cellular Therapies:
1. Hematopoietic Stem Cell Therapies in hepatic diseases - Inst Fundeni
2. Clinical applications of the Cellular Therapies in hepatic diseases - Inst Fundeni
3. Mesenchimal Stem Cell Therapies in re-epithelization processes - UMF Timisoara
4. pancreatic beta cells in diabet and regenerative medicine - Inst Fundeni
5. Methods for improving pancreatic islands viability after isolation and transplant.
6. The engineering of a glucose-responsive insuline secretory cell-line for therapeutic application;
7. Exocytosis and fussion of secretory granulae with the cellmembrane in pancreatic beta cells lines - IB
8. Laser cell transfer for tissular engineering and organ reconstruction - INCD Laser Physics
• Module 4: Biomaterials, nanostructures and pharmacophores:
1. Antiviral drug design for hep B and C viruses - IB
2. Nanostructures for controlled drug release - INCD Laser Physics
3. Directional synthesis and screening of stresso-protective compoundse - UB
4. Lasser applications in nanostructures for controlled drug administration, implants and tissue reconstruction - INCD Laser Physics
5. Biomaterial laser nanostructuring for pharmaceutical applications - INCD Laser Physics
6. Implant nanostructure biocompatibility si bioactivity - INCD Laser Physics

Post Docs 2010

Post Docs 2011

Post Docs 2012

Publications

• Filimon A, Zurac SA, Milac AL, Sima LE, Petrescu SM, Negroiu G, "Value of dopachrome tautomerase detection in the assessment of melanocytic tumors." Melanoma Res., 24(3), 219-236 (2014)
  IF = 2.51
• Axente E, Sima F, Sima LE, Erginer M, Eroglu MS, Serban N, Ristoscu C, Petrescu SM, Oner ET, Mihailescu IN, "Combinatorial MAPLE gradient thin film assemblies signalling to human osteoblasts." Biofabrication, 6, 035010 (2014)
  IF = 3.70
• Cucu D, Chiritoiu G, Petrescu S, Babes A, Stanica L, Duda DG, Horii A, Dima SO, Popescu I, "Characterization of Functional Transient Receptor Potential Melastatin 8 Channels in Human Pancreatic Ductal Adenocarcinoma Cells." Pancreas, in press (2014)
  IF = 2.95
• Popa I, Ganea E, Petrescu SM, "Expression and subcellular localization of RAGE in melanoma cells." Biochem.Cell.Biol., 92(2), 127-136 (2014)
  IF = 2.91
• Wypijewska Del Nogal A, Surleac MD, Kowalska J, Lukaszewicz M, Jemielity J, Bisaillon M, Darzynkiewicz E, Milac AL, Bojarska E, "Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.." FEBS J, 280(24), 6508-6527 (2013)
  IF = 4.25
• Uyy E, Ivan L, Boteanu RM, Suica VI, Antohe F, "Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.." Cell Tissue Res., 354(3), 771-781 (2013)
  IF = 3.67
• Petrareanu C, Macovei A, Sokolowska I, Woods AG, Lazar C, Radu GL, Darie CC, Branza-Nichita N, "Comparative Proteomics Reveals Novel Components at the Plasma Membrane of Differentiated HepaRG Cells and Different Distribution in Hepatocyte- and Biliary-Like Cells." PLoS One, 8(8), e71859 (2013)
  IF = 4.09
• Dinca V, Florian PE, Sima LE, Rusen L, Constantinescu C, Evans RE, Dinescu M, Roseanu A, "MAPLE-based method to obtain biodegradable hybrid polymeric thin films with embedded antitumoral agents." Biomed.Microdev., DOI 10.1007/s10544-013-9801-9, July (2013)
  IF = 2.71
• Stroescu A, Sima L, Pena F, "Current methods for investigation of the unfolded protein response." Rom.Biotech.J., 18(4), 8539-8550 (2013)
  IF = 0.34
• Corotchi MC, Popa MA, Remes A, Sima LE, Gussi I, Plesu ML, "Isolation method and xeno-free culture conditions influence multipotent differentiation capacity of human Wharton.s jelly-derived mesenchymal stem cells." Stem Cell Res.Ther., 4, 81 (2013)
  IF = 3.65
• Rowe IA, Galsinh SK, Wilson GK, Parker R, Durant S, Lazar C, Branza-Nichita N, Bicknell R, Adams DH, Balfe P, McKeating JA, "Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication." Hepatology., [e-pub ahead of print - doi: 10.1002/hep.26571] (2013)
  IF = 12.00
• Slootweg EJ, Spiridon LN, Roosien J, Butterbach P, Pomp R, Westerhof L, Wilbers R, Bakker E, Bakker J, Petrescu AJ, Smant G, Goverse A, "Structural Determinants at the Interface of the ARC2 and LRR Domains Control the Activation of the NB-LRR Plant Immune Receptors Rx1 and Gpa2." Plant Physiol., 162(3), 1510-1528 (2013)
  IF = 6.53
• Mindroiu M, Ion R, Pirvu C, Cimpean A, "Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy." Mat.Sci.Eng.C, 33(6), 3353-3361 (2013)
  IF = 2.40
• Vicas SI, Teusdea AC, Carbunar M, Socaci SA, Socaciu C "Glucosinolates Profile and Antioxidant Capacity of Romanian Brassica Vegetables Obtained by Organic and Conventional Agricultural Practices." Plant.Foods.Hum.Nutr., DOI 10.1007/s11130-013-0367-8 (2013)
  IF = 2.35
• Craciunescu O, Moldovan L, Moisei M, Trif M "Liposomal formulation of chondroitin sulfate enhances its antioxidant and anti-inflammatory potential in L929 fibroblast cell line." J.Liposome Res., 23(2), 145-153 (2013)
  IF = 1.70
• Macovei A, Petrareanu C, Lazar C, Florian P, Branza-Nichita N, "Regulation of Hepatitis B Virus infection by Rab5, Rab7 and the endo-lysosomal compartment." J.Virol., 87(11), 6415-6127 (2013)
  IF = 5.40
• Mindroiu M, Ungureanu C, Ion R, Pirvu C, "The effect of deposition electrolyte on polypyrrole surface interaction with biological environment." Appl.Surf.Sci., [e-pub ahead of print, http://dx.doi.org/10.1016/j.apsusc.2013.03.107] (2013)
  IF = 2.10
• Pauna IA, Mihailescu M, Calenic B, Luculescu CR, Greabu M, Dinescu M, "MAPLE deposition of 3D micropatterned polymeric substrates for cell culture." Appl.Surf.Sci., [e-pub ahead of print, http://dx.doi.org/10.1016/j.apsusc.2013.03.106] (2013)
  IF = 2.10
• Bleotu C, Pircalabioru G, Dragusel R, Aldea I-M, Botezatu A, Banu O, Mihaescu G, Cernescu E-C, Diaconu CC, "Active protein and calcium hydroxyapatite bilayers grown by laser techniques for therapeutic applications." Curr.Org.Chem., 17(2), 137-142 (2013)
  IF = 3.06
• Socaci SA, Socaciu C, Tofana M, Rati IV, Pintea A, "In-tube Extraction and GC.MS Analysis of Volatile Components from Wild and Cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) Berry Varieties and Juice." Phytochem.Anal., [Epub ahead of print] (2013)
  IF = 2.63
• Marcu A, Pop S, Dumitrache F, Mocanu M, Niculite CM, Gherghiceanu M, Lungu CP, Fleaca C, Ianchis R, Barbut A, Grigoriu C, Morjan I, "Magnetic iron oxide nanoparticles as drug delivery system in breast cancer." Appl.Surf.Sci., [Epub ahead of print] (2013)
  IF = 2.10
• Mentel M, Iancu I, Kibedi-Szabo CZ, Munteanu CVA, Szedlacsek SE, "Co-expression of Human WDR1 Gene With a Chaperone Increases its Protein Solubility." Rom J. Biochem., 50(1), 39-52 (2013)
• Petrareanu G, "The Molecular and Cellular Characterization of a Non-Receptor Protein Tyrosine Phosphatase." Rom J. Biochem., 50(1), 65-72 (2013)
• Marcu A, Enculescu I, Vizireanu S, Birjega R, Porosnicu C, "Magnetic iron oxide nanoparticles as drug delivery system in breast cancer." Digest J.Nanom.Biostruc., 8(2), 597-605 (2013)
  IF = 1.20
• Motoc MM, Axente E, Popescu C, Sima LE, Petrescu SM, Mihailescu IN, Gyorgy E, "Active protein and calcium hydroxyapatite bilayers grown by laser techniques for therapeutic applications." J Biomed Mater Res A., [Epub ahead of print] (2013)
  IF = 2.62
• Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita N, "Characterization of the anti-HBV activity of HLP1.23, a human lactoferrin-derived peptide." J.Med.Vir., 85(5), 780-788 (2013)
  IF = 2.82
• Hurduc N, Macovei A, Paius C, Raicu A, Moleavin I, Branza-Nichita N, Hamel M, Rocha L "Azo-polysiloxanes as new supports for cell cultures." Mat.Sci.Eng.C., 33(4), 2440-2445 (2013)
  IF = 2.68
• Flangea C, Mosoarca C, Cozma C, Galusca M, Przybylski M, Zamfir AD, "Testing the feasibility of fully automated chip-based nanoelectrospray ionization mass spectrometry as a novel tool for rapid diagnosis of Fabry disease." Electophoresis., [e-pub ahead of print] (2013)
  IF = 3.30
• Flangea C, Petrescu AJ, Seidler DG, Munteanu CVA, Zamfir AD, "Identification of an unusually sulfated tetrasaccharide chondroitin/dermatan motif in mouse brain by combining chip- nanoelectrospray multistage MS2-MS4 and high resolution mass spectrometry." Electophoresis., 34(11), 1581-1592 (2013)
  IF = 3.30
• Potel J, Rassam P, Montpellier C, Kaestner L, Werkmeister E, Tews BA, Couturier C, Popescu CI, Baumert TF, Rubinstein E, Dubuisson J, Milhiet PE, Cocquerel L, "EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry." Cell Microbiol., [e-pub ahead of print] (2013)
  IF = 5.45
• David-Rus D, "Mathematical framework of epigenetic DNA methylation in gene body arabidopsis." Digest.J.Nanomat.Biostruct., 8(1), 227-237 (2013)
  IF = 1.20
• Ciubotaru M, Trexler AJ, Spiridon LN, Surleac MD, Rhoades E, Petrescu AJ, Schatz DG, "RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes." Nucl.Acid.Res., 41(4), 2437-2454 (2013)
  IF = 8.02
• Diaconeasa A, Boda D, Solovan C, Enescu DM, Vilcea AM, Zurac S, " Histopathologic features of Spitzoid lesions in different age groups. " Rom. J. Morphol.Embryol., 54(1), 3-6 (2013)
  IF = 0.52
• Zamfir AD, Flangea C, Serb A, Zagrean AM, Rizzi AM, Sisu E, "Separation and identification of glycoforms by capillary electrophoresis with electrospray ionization mass spectrometric detection.." Methods Mol Biol., 951, 145-169 (2013)
• Paius CM, Macovei A, Branza-Nichita N, Rocha L, Hurduc N, "Nanostructured azo-polysiloxanic films for biological applications." Env.Eng.Manag.J., 11(11), 2029-2034 (2012)
  IF = 1.00
• Bubenek S, Nastase A, Niculescu AM, Baila S, Herlea V, Lazar V, Paslaru L, Botezatu A, Tomescu D, Popescu I, Dima S, "Assessment of gene expression profiles in peripheral occlusive arterial disease." Can.J.Cardiol., 28(6), 712-720 (2012)
  IF = 3.35
• Vicas SI, Fetea F, Carbunar M, Socaciu C, "Comparative Fingerprint of Glucosinolates from Brassica Vegetables Using HATR/FT-MIR Spectroscopy." Bull. UASVM Agr., 69(2), 430-439 (2012)
• Cean A, Istratoaie B, Cristea M, Ivan A, Anghel S, Bojin F, Tanasie G, Tatu C, Panaitescu C, Paunescu V, " The morphology of colonies from breast cancer SK-BR-3 cells in semisolid media depends on the media composition. " Fiziologia, 75 (2012.23.3), 9-14 (2012)
• Zurac S, Negroiu G, Petrescu S, Andrei R, Tebeica T, Popp C, Mustata R, Neagu M, Constantin C, Solovan C, Chi�u V, Rebosapcs A, Andreescu B, Marinescu I, Staniceanu F, "Spectrum of Morphologic Alterations of Regression in Cutaneous Melanoma - Potential for Improving Disease Prognosis." Rom.J.Int.Med, 50(2), 145-153 (2012)
• Grigorie R, Herlea V, Nastase A, Pechianu C, Purnichescu-Purtan R, Dima S, Popescu I, " Correlation of Glypican-3 Expression with Clinicopathologic Features of Hepatocellular Carcinoma Patients Treated by Liver Transplantation. " Annals Fundeni Hosp., 17(1-2) 3-7 (2012)
• David-Rus D., "Protein Synthesis- Degradation, A Stochastic Approach - Part I." arXiv.org>q-bio., 1212.0658 (2012)
• Sarandan H, Decun M, Paunescu V, Ordodi V, Bojin F, Hutu I, Pop C, Zarcula S, Burian C, Tanasie G, Sarandan M, " Deoxynivalenol and Ochratoxin A inactivation in broiler chickens' feed." Rom.Biotech.Lett., 17(6), 7825-7834 (2012)
  IF = 0.21
• Ulmeanu M, Anghel I, Filipescu M, Luculescu C, Enculescu M, Zamfirescu M, "Periodic arrays of nanostructures in silicon and gallium arsenide by near-field enhanced laser irradiation in liquid precursors." Colloid.Surf.A., 418, 47-51 (2013)
  IF = 2.23
• Avram S, Milac AL, Carta F, Supuran CT, "More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design." J Enzyme Inhib Med Chem., 28(2), 350-359 (2013)
  IF = 1.61
• Bohmer F, Szedlacsek S, Tabernero L, Ostman A, den Hertog J, "Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis." FEBS J., doi: 10.1111/j.1742-4658.2012.08655.x. (2012)
  IF = 3.79
• Sima F, Axente E, Sima LE, Tuyel U, Eroglu MS, Serban N, Ristoscu C, Petrescu SM, Toksoy Oner E, Mihailescu IN, "Combinatorial matrix-assisted pulsed laser evaporation: Single-step synthesis of biopolymer compositional gradient thin film assemblies." Appl.Phys.Lett., 101, 233705 (2012)
  IF = 3.84
• Virgolici B, Alexandru P, Lixandru D "Physiological and dysfunctional secretion of insulin." Rom.J.Biochem., 49(2), 211-220 (2012)
• Popa I, Ganea E, Petrescu SM "RAGE over AGEs and DAMPs." Rom.J.Biochem., 49(2), 195-210 (2012)
• Pena F, Petrescu SM "The unfolded protein response and hypoxic stress." Rom.J.Biochem., 49(2), 183-194 (2012)
• Gaspar A, Craciunescu O, Moldovan L, Ganea E "New composites collagen - polyphenols as potential dressing for wound care." Rom.J.Biochem., 49(2), 173-181 (2012)
• Craciunescu O, Moldovan M, Roseanu R, Moisei M, Gaspar A, Stanciuc A-M, Constantin D, Trif T "Lipid vesicles entrapping bioactive agents protect chondrocyte cells against hydrogen peroxide-induced inflammation." Rom.J.Biochem., 49(2), 139-152 (2012)
• Parvulescu V, Niculescu V, Ene R, Popa A, Mureseanu M, Ene CD, Andruh M. "Supported monocationic copper(II) complexes obtained by coordination with dialkylphosphonate groups on styrene-divinylbenzene copolymer as catalysts for oxidation of organic compounds." J.Mol.Catal.A:Chem., 366, 275-281 (2013)
  IF = 2.95
• Flangea C, Schiopu C, Capitan F, Mosoarca C, Manea M, Sisu E, Zamfir AD. "Fully automated chip-based nanoelectrospray combined with electron transfer dissociation for high throughput top-down proteomics." Centr.Eur.J.Chem, 11(1), 25-34 (2013)
  IF = 1.07
• Paun IA, Ion V, Luculescu C-R, Dinescu M, Canulescu S, Schou J, "In vitro studies of PEG thin films with different molecular weights deposited by MAPLE." Appl Phys A, 109, 223 - 232 (2012)
  IF = 1.63
• Popovici E, Luculescu C, Alexandrescu R, Fleaca C, Dumitrache F, Barjega R, Scarisoreanu M, Dutu E, Barbut A, Morjan I, Vasile E "Development of systems for the laser synthesis of nanoparticles starting from liquid precursors." Appl.Surf.Sci., 258, 9326 - 9332 (2012)
  IF = 2.10
• Ion FM, Barna V, Vulpe S, Radu A, Filimon A, Heimann-Gentiana D. "Fabrication and Characterization of Thin Polyaniline Films Obtained by Glancing Angle Deposition (Glad) Technique." Digest J. Nanomat. Biostruct 7(4), 1481 - 1490 (2012)
  IF = 1.20
• Surleac MD, Spiridon LN, Tacutu R, Milac AL, Petrescu SM, Petrescu A-J, "The Structural Assessment of Glycosylation Sites Database - SAGS. An overall view on N-glycosylation.", Glycosylation, Petrescu SM (ed), InTech, ISBN 980-953-307-130-0, Chapter 1, pp 1-20 (2012)
• Cristescu R, Popescu C, Socol G, Iordache I, Mihailescu IN, Mihaiescu DE, Grumezescu AM, Balan A, Stamatin I, Chifiriuc C, Bleotu C, Saviuc C, Popa M, Chrisey DB, "Magnetic core/shell nanoparticle thin films deposited by MAPLE: Investigation by chemical, morphological and in vitro biological assays.", Appl.Sci.Surf, 258(23),9250-9255 (2012)
  IF = 2.10
• Muntean DM, Ordodi V, Ferrerac R, Angoulvant D, "Volatile anaesthetics and cardioprotection - lessons from animal studies.", Fund&Clin.Pharmacol, DOI: 10.1111/j.1472-8206.2012.01055.x, (2012)
  IF = 1.79
• Sarandan M, Ordodi V, Morvay AA, Decun M, Sala C, Morar A, Burian C, "Electrochemical Bypass of Bacterial Biofilms' Defences.", Lucrari St.Med.Vet, XLV(2), 148-151 (2012)
• Burian C, Ordodi V, Cristina RT, Morvay AA, Decun M, Sala C, Morar A, Sarandan M, "Water Disinfection Using an Electrochemical Reactor with Asymmetric Current Densities.", Lucrari St.Med.Vet, XLV(2), 100-103 (2012)
• Mitrica R, Dumitru I, Ruta LL, Ofiteru AM, Farcasanu IC, "Dual Action of Epigallocatechin Gallate (EGCG), the Main Constituent of Green Tea, against the Deleterious Effects of Visible Light and Singlet Oxygen-Generating Conditions as Seen in Yeast Cells.", Molecules, 17(9), 10355-10369 (2012)
  IF = 2.38
• Marin BM, Ghenea S, Spiridon LN, Chiritoiu GN, Petrescu AJ, Petrescu SM, "Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.", PlOS One, 7(8), e42998 (2012)
  IF = 4.41
• Sokolowska I, Dorobantu C, Woods AG, Macovei A, Branza-Nichita N, Darie CC "Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells.", Proteome Sci, 10(1), 47 (2012)
  IF = 2.33
• Ulmeanu M, Jipa F, Radu C, Enculescu M, Zamfirescu Z, "Large scale microstructuring on silicon surface in air and liquid by femtosecond laser pulses", Appl.Surf.Sci, 258, 9314-9317 (2012)
  IF = 2.03
• Branza-Nichita N, Macovei A, Lazar C "Caveolae-Dependent Endocytosis in Viral Infection", in Molecular Recognition of Endocytosys, Ceresa B (ed), Intech, Croatia, ISBN 978-953-51-0662-3, pp 155-183 (2012)
• Dumitru I, Ene CD, Ofiteru AM, Paraschivescu C, Madalan AM, Baciu I, Farcasanu IC "Identification of [CuCl(acac)(tmed)], a copper(II) complex with mixed ligands, as a modulator of Cu,Zn superoxide dismutase (Sod1p) activity in yeast" J.Biol.Inorg.Chem. 7(6), 961-974 (2012)
  IF = 3.29
• Necula LG, Chivu-Economescu M, Stanciulescu EL, Bleotu C, Dima SO, Alexiu I, Dumitru A, Constantinescu G, Popescu I, Diaconu CC,, "IL-6 and IL-11, as markers for tumor aggressiveness and prognosis in gastric adenocarcinoma patients without mutations in Gp130 subunits" J.Gastrointestin.Liv.Dis. 21(1), 23-29 (2012)
  IF = 1.73
• Luca C, Buburuzan L, Romanescu D, Gaina G, Stanescu C, Sandolache B, Popescu I, Botnarciuc V, Costache M, "Analysis of p53 gene polymorphisms in Romanian patients with squamous cell oesophageal carcinoma" Rom.Biotech.Lett 17(1), 6921-6927 (2012)
  IF = 0.15
• Bacanu EV, Lixandru D, Stoian I, Ionescu-Targoviste C, " Paraoxonase 1 could reverse the oxidative changes induced by triglyceride-rich lipoproteins in diabetes. " Proc. Rom.Acad, Series B 2012(1), 20-26 (2012)
• Munteanu CVA, Alexandru P, Spiridon LN, Petrescu AJ, Milac AL, "Insights Into Cecropin-Membrane Interaction Mechanism Given By Molecular Dynamics Simulations." Rom.J.Biochem. 49(1), 21-31 (2012)
• Hrehoret D, Alexandrescu S , Grigorie R, Herlea V, Anghel R, Popescu I. "Intrahepatic cholangiocarcinoma - a rare indication for liver transplantation." Chirurgia 107(2), 237-242 (2012)
  IF = 0.56
• Coman C, Rugina OD, Socaciu C. "Plants and Natural Compounds with Antidiabetic Action." Notulae Botanicae Horti Agrobotanici 40(1), 314-325 (2012)
  IF = 0.46
• Socol G, Socol M, Sima L, Petrescu S, Enculescu M, Sima F, Miroiu M, Popescu-Pelin G, Stefan N, Cristescu R, Mihailescu CN, Stanculescu A, Sutan C, Mihailescu IN. "Combinatorial Pulsed Laser Deposition of Ag-Containing Calcium Phosphate Coatings." Digest J. Nanomat. Biostruct 7(2), 563-576 (2012)
  IF = 1.02
• Floroian L, Florescu M, Sima F, Popescu-Pelin G, Ristoscu C, Mihailescu IN. "Synthesis of biomaterial thin films by pulsed laser technologies: Electrochemical evaluation of bioactive glass-based nanocomposite coatings for biomedical applications." Mat.Sci.Eng C32, 1152-1157 (2012)
  IF = 2.18
• Marcu A, Trupina L, Zamani R, Arbiol J, Grigoriu C, Morante JR. "Catalyst Size Limitation in Vapor-Liquid-Solid ZnO Nanowire Growth using Pulsed Laser Deposition." Thin Solid Films 520, 4626 (2012)
  IF = 1.90
• Florian P, Macovei A, Sima L, Nichita N, Mattsby-Baltzer I, Roseanu A. "Endocytosis and trafficking of human lactoferrin in macrophage-like human THP-1 cells." Biochem. Cell. Biol. 90(3), 449-455 (2012)
  IF = 2.99
• Vaszilcsina N, Ordodi V, Borza A. "Corrosion inhibitors from expired drugs." Int.J.Pharmaceutics 431, 241-244 (2012)
  IF = 3.60
• Bacanu EV, Lixandru D, Stoian I, Vargolici B, Mohora M, Arsene AL, Ionescu-Targoviste C. "Correlations between Obesity Antropometric Markers, Adipocytokines and Monocytes Oxidative Stress Status in type 2 Diabetic Patients." Farmacia 2, 194-205 (2012)
  IF = 0.85
• Avram S, Milac AL, Mihailescu D. "3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A." Mol.Biosys. 8(5),1418-1425 (2012)
  IF = 3.82
• Dima SO, Tanase C, Albulescu R, Botezatu A, Popescu I. "Novel Biomarkers in Pancreatic Cancer.", Cap.3 in Pancreatic Cancer - Clinical Management. InTech, Srivastava SK (ed), ISBN: 978-953-51-0394-3, pp.41-54 (2012)
• Lazar C, Macovei A, Petrescu SM, Branza-Nichita N. "Activation of ERAD Pathway by Human Hepatitis B Virus Modulates Viral and Subviral Particle Production.", PLoS One. 7(3), e34169 (2012)
  IF = 4.41
• Ofiteru AM, Ruta LL, Rotaru C, Dumitru I, Ene CD, Neagoe A, Farcasanu IC. "Overexpression of the PHO84 gene causes heavy metal accumulation and induces Ire1p-dependent unfolded protein response in Saccharomyces cervisiae cells.", Appl.Microbiol.Biotechnol. 94, 425-435 (2012)
  IF = 3.28
• Avram S, Mihailescu D, Borcan F, Milac AL. "Prediction of improved antimicrobial mastoparan derivatives by 3D-QSAR-CoMSIA/CoMFA and computational mutagenesis.", Chem.Month. 143(4), 535-543 (2012)
  IF = 1.36
• Bojin FM, Gruia AT, Cristea MI, Ordodi VL, Paunescu V, Mic FA. "Adipocytes Differentiated In Vitro from Rat Mesenchymal Stem Cells Lack Essential Free Fatty Acids Compared to Adult Adipocytes.", Stem Cells & Develop. 21(4), 507-512 (2012)
  IF = 4.79
• Sela H, Spiridon LN, Petrescu A-J, Akerman M, Mandel-Gutfreund Y, Nevo E, Loutre C, Keller B, Schulman AH, Fahima T. "Ancient diversity of splicing motifs and protein surfaces in the wild emmer wheat (Triticum dicoccoides) LR10 coiled coil (CC) and leucine-rich repeat (LRR) domains.", Mol. Plant Pathol. 13(3), 276-287 (2012)
  IF = 3.70
• Boleman-Ivan A, Tanasie G, Galuscan A, Cristea MI, Bojin FM, Panaitescu C, Paunescu V. "Studies Regarding the in vitro Wound Healing Potential of Mouse Dental Pulp Stem-Like Progenitor Cells.", Biotechnology & Biotechnological Equipment. 26(1), 2781-2785 (2012)
  IF = 0.50
• Avram S, Buiu C, Borcan F, Milac AL "More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis.", Mol Biosyst., 8(2), 587-594 (2012)
  IF = 3.82
• Ene CD, Lungu A, Mihalciuc C, Hillebrand M, Ruiz-Perez C, Andruh M, " Pentacyanido(L)ferrate(III) complexes: Crystal structures, electrochemical and DFT studies.", Polyhedron, 31(1), 539-547 (2012)
  IF = 2.03
• Pascariu MC, Sisu E, Ordodi VL, Rusnac LM, " Spectral Analysis of Diisopropylidenated Monosaccharides. Low Energy EI-MS Fragmentation Study. ", Chem Bull "Polytehnica" Univ. Timisoara., 56(20), 6-11 (2011)
• Paun IA, Moldovan A, Luculescu CR, Dinescu M, "Biocompatible polymeric implants for controlled drug delivery produced by MAPLE.", Appl.Surf.Sci., 257(24), 10780-10788 (2011)
  IF = 1.79
• Surdu-Bob CC, Coman C, Calugaru A, Cremer L, Badulescu M, Vlase E "Biocompatible polymeric implants for controlled drug delivery produced by MAPLE.", Proc 4th Eur-Conf.Clin.Nanomed., Part IV, 145-146 (2011)
• Bunea A, Rugina DO, Pintea AM, Sconta Z, Bunea CI, Socaciu C, "Comparative Polyphenolic Content and Antioxidant Activities of Some Wild and Cultivated Blueberries from Romania.", Notulae Botanicae Horti Agrobotanici, 39(2), 70-76 (2011)
  IF = 0.46
• Rugina DO, Sconta Z Pintea AM, Bunea A, Socaciu C, "Protective Effect of Chokeberry Anthocyanin-rich Fraction at Nanomolar Concentrations against Oxidative Stress Induced by High Doses of Glucose in Pancreatic b-cells.", Bull. UASVM Vet.Med, 68(1), 114-119 (2011)
• Zamfirescu M, Ulmeanu M, Bunea A, Sajin G, Dabu R, " Ultrashort Pulsed Lasers . Efficient Tools for Materials Micro-Processing.", Recent Advances in Nanofabrication Techniques and Applications, Cui B (ed), In Tech, ISBN 978-953-307-602-7, pp 1336-1340 (2011)
• Surdu-Bob CC, Racolta PM, Badulescu M, Chiojdeanu C, Arsene N, Logofata C, Ionescu C, Sporea D, Gruia I "Pure, smooth and dense W films obtained by an anodic arc plasma.", Optoel & Adv.Mat., 5(12), 1336-1340 (2011)
  IF = 0.48
• Buburuzan L, Luca C, Tica M, Tica V, Vrabie C, Botnarciuc V, Popescu I, Costache C "Loss of heterozygosity at the BRCA1 locus in Romanian cancer patients 6601.", Rom.Biotech.Lett., 16(5), 6601-6611 (2011)
  IF = 0.05
• Dorobantu C, Macovei A, Lazar C, Dwek R.A., Zitzmann N., Branza-Nichita N. "Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein.", J.Virol., 85(24), 13373-13383 (2011)
  IF = 5.17
• Bojin FM, Gavriliuc OI, Cristea MI, Tanasie G, Tatu CS, Panaitescu C, Paunescu V, "Telocytes within human skeletal muscle stem cell niche.", J.Cell&Mol.Med., 15(10), 2269-2272 (2011)
  IF = 4.61
• Cucu D, D.Haese PC, De Beuf A, Verhulst A, "Low Doses of Cadmium chloride and methallothionein-1-bound cadmium display different accumulation kinetics and induce different genes in cells of the human nephron.", Nephron Extra, 1, 24-37 (2011)
• Popescu CI, Rouille Y, Dubuisson J, "HCV replication and assembly: a play in one act.", Future Virol., 6(8), 985-995 (2011)
  IF = 1.20
• Popescu CI, Rouille Y, Dubuisson J, "HCV assembly imaging.", Viruses-Basel, 3(11), 2238-2254 (2011)
  IF = 1.00
• Gruia AT, Barbu-Tudoran L, Mic AA, Ordodi VL, Paunescu V, Mic FA "Arachidonic acid accumulates in the stromal macrophages during thymus involution in diabetes.", Histochem.Cell Biol., 136(1), 79-92 (2011)
  IF = 4.73
• Ivan L, Dima SO, Antohe F, "Heat Shock Proteins in Pancreatic Diseases.", Rom.J.Biochem., 41(1), 65-74 (2011)
  IF = -
• Ghenea S, "Caenorhabditis Elegans as a Model Organism for ER-Related Diseases.", Rom.J.Biochem., 41(1), 51-64 (2011)
  IF = -
• Cucu D, Dima S-O, "Ion Channels Involved in the Inflammatory Processes of the Digestive System.", Rom.J.Biochem., 41(1), 41-50 (2011)
  IF = -
• Buburuzan L, Luca C, "MAP4K4 a possible new biomarker in cancer therapy.", Anal.St.Univ.AICuza, sect. Gen.&Biol.Mol., XII(2), 25-32 (2011)
  IF = -
• Luca C, Buburuzan L, Schipor S, Badiu C, Dinischiotu A, Stefanescu A-M, Costache M, "SDHB gene polymorphisms detection in Romanian patients with pheochromocytoma.", Analele SRBC, 1, 11-15 (2011)
  IF = -
• Radu C, Simion S, Zamfirescu M, Ulmeanu M, Enculescu M, Radoiu M, "Silicon structuring by etching with liquid chlorine and fluorine precursors using femtosecond laser pulses.", J.Appl.Phys., 110, 034901 (2011)
  IF = 2.06
• Ulmeanu M, Jipa F, Luculescu C, Moldovan A, Zamfirescu M, "Single pulse near field study on a Co(3 nm)/Cu(6 nm)/Co(20 nm) multilayer structure by using a femtosecond laser.", Appl Phys A, 104, 839-843 (2011)
  IF = 1.76
• Surdu-Bob CC, Coman C, Calugaru A, Cremer L, Badulescu M, Vlase E, "Implant Microparticles - A New Concept for Non-Invasive Cancer Therapy.", Rom.Arch. Microbiol&Immunol, 70(1), 37-41 (2011)
  IF = -
• Ulmeanu M, Filipescu N, Scarisoreanu ND, Georgescu G, Rusen L, Zamfirescu M, "Selective removal and patterning of a Co/Cu/Co trilayer created by femtosecond laser processing,.", Applied Physics A, 104, 247-255 (2011)
  IF = 1.59
• Cioaca D, Ghenea S, Spiridon LN, Marin M, Petrescu AJ, Petrescu SM, "C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.", PLoS One, 6 (5), e19979 (2011)
  IF = 4.35
• Maekawa T, Cheng W, Spiridon LN, T�ller A, Lukasik E, Saijo Y, Liu P, Shen Q, Micluta MA, Somssich IE, Takken FL, Petrescu AJ, Chai J, Schulze-Lefert P, "Coiled-coil domain-dependent homodimerization of intracellular barley immune receptors defines a minimal functional module for triggering cell death.", Cell Host Microbe, 9 (3), 187-199 (2011)
  IF = 13.02
• Grozav AG, Willard BB, Kozuki T, Chikamori K, Micluta MA, Petrescu AJ, Kinter M, Ganapathi R, Ganapathi MK, "Tyrosine 656 in topoisomerase II. is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.", Proteomics, 11 (5), 829-842 (2011)
  IF = 4.42
• Popescu CI, Callens N, Trinel D, Roingeard P, Moradpour D, Descamps V, Duverlie G, Penin F, H�liot L, Rouill� Y, Dubuisson J, "NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.", PLoS Pathogenes, 7 (2), e1001278 (2011)
  IF = 8.98
• Ionel L, Cristescu CP, Jipa F, Enculescu M, Radoiu M, Dabu R, Zamfirescu M, Ulmeanu M, "Nano and micro-morphology modifications of Si (100) substrate induced by femtosecond laser pulse irradiations in air, water, CCl4 and C2Cl3F3", Optoelectronics and Advanced Materials - Rapid Communications, 4 (11), 1920-1924 (2010)
  IF = 0.45
• Boleman A, Cristea MI, Gruia A, Anghel S, Tanasie G, Bunu C, Paunescu V, "Small interfering RNAs and the RNA interference phenomenon.", Fiziologia J.., 20(4/68), 9-13 (2010)
  IF = -
• Helle F, Vieyres G, Elkrief L, Popescu CI, Wychowski C, Descamps V, Castelain S, Roingeard P, Duverlie G, Dubuisson J, "Role of N-linked glycans in the functions of HCV envelope proteins incorporated in infectious virions.", J Virol., 84(22), 11905-11915 (2010)
  IF = 5.15
• Tews BA, Popescu CI, Dubuisson J, "Last Stop Before Exit - Hepatitis C Assembly & Release as Antiviral Drug Targets", Viruses-Basel, 2, 1782-1803 (2010)
  IF = 1.00
• Rugina D, Vicas S, Petran M, Pintea A, Bunea A, Socaciu C, "Preliminary Research Regarding the Antitumor Effects of Mistletoe on A2780 Cells", Bul.UASVM Animal Sci.&Biotech., 67, 429-436 (2010)
• Codita I, Caplan D, Dragulescu EC, Lixandru EB, Coldea L, Surdu-Bob C, Badulescu M, "Antimicrobial Activity of Copper and Silver Nanofilms on Nosocomial Bacterial Species", Rom. Arch. Microbiol. & Immunol., 69 (4), 204-212 (2010)

Submitted Patents

• Popovici E, Morjan I, Alexandrescu R, Voicu I, Gavrila Florescu C-L, Morjan I, Luculescu R, Dumitrache F, Sandu I, Fleaca C-T, Scarisoreanu G-M, Dutu E, Barbut A-D, "Brevet OSIM-A_201100394-270411: "Instalatie de sinteza cu laser de mare productivitate de nanostructuri din precursori lichizi cu mare toxicitate si periculozitate prin vaporizare termica cu obtinerea fazei gazoase la temperaturi peste limita temperaturii de fierbere si sub limita temperaturii de descompunere cu control automat precis si riguros al temperaturii pana la 500 0C cu grad mare de reproductibilitate a sintezei." Buletinul Oficial de Proprietate Industrial.-BOPI, Sectiunea Brevete de Inventie,9/2012, bopi_inv_0911_2012, pg. 27, (2012)
• Popovici E, Morjan I, Alexandrescu R, Voicu I, Gavrila F, Carmen L , Morjan I, Luculescu R-C, Dumitrache F, Sandu I, Fleaca C-T, Scarisoreanu G-M-, Dutu E, Barbut A-D, Niculescu A, "Brevet OSIM-2011-01196-221111: "Ansamblu de electrozi a-k de descarcare de inalta tensiune pentru laserii de mare putere cu co2 cu circulatia transversala a gazelor gt-1200." Buletinul Oficial de Proprietate Industrial.-BOPI, Sectiunea Brevete de Inventie, 7/2012, bopi_inv_0712_2012, pg. 58 (2012)
• Surdu- Bob CC, Badulescu M, Iacob C, "Nanocompozit antimicrobian ecologic, permanent si cu spectru larg de actiune si echipament pentru realizarea acestuia." Reg.Dep.OSIM: A / 01267 / 02.12.2010 (2010)
• Marin M, Ghenea S, Petrescu SM, "Anticorpi policlonali anti EDEM 1." Reg.Dep.OSIM: A / 00988 / 18.10.2010 (2010)
• Chiritoiu G, Ghenea S, Petrescu SM, "Anticorpi policlonali anti EDEM 2." Reg.Dep.OSIM: A / 00989 / 18.10.2010 (2010)
• Ghenea S, Alexandru P, Petrescu SM, "Anticorpi policlonali anti EDEM 3." Reg.Dep.OSIM: A / 00990 / 18.10.2010 (2010)