Aura-Elena Ionescu, PhD student

Group: Enzymology
Department: EnzymologyScientific Researcher
Research interests: Signaling pathways in cancer,
Mass spectrometry,
Protein expression and purification.
Biography
Born: 19th of November 1988, Ploiesti, Romania
2003 - 2007: „Ion Luca Caragiale” National College, Ploieşti, Romania
2007- 2012: Faculty of Pharmacy at University of Medicine and Pharmacy "Carol Davila" Bucharest
2012 - now: Institute of Biochemistry of the Romanian Academy
2003 - 2007: „Ion Luca Caragiale” National College, Ploieşti, Romania
2007- 2012: Faculty of Pharmacy at University of Medicine and Pharmacy "Carol Davila" Bucharest
2012 - now: Institute of Biochemistry of the Romanian Academy
Papers
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. "Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo", Cancer biology & therapy: 1-16, (2021)
IF: 4.74 -
. "Regulation of TRPM8 channel activity by Src-mediated tyrosine phosphorylation", Journal of Cellular Physiology 235(6): 5192-5203, (2020)
IF: 4.52AI: 1.50 -
. "Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation", International Journal of Molecular Sciences 20(24): 6307, (2019)
IF: 4.18 -
. "WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton", Scientific reports 8(1): 2910, (2018)
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. "Expression, Purification, and Kinetic Analysis of PTP Domains", Methods in molecular biology (Clifton, N.J.) 1447: 39-66, (2016)
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. "Phosphoketolases from Lactococcus lactis, Leuconostoc mesenteroides and Pseudomonas aeruginosa: Dissimilar sequences, similar substrates but distinct enzymatic characteristics", Applied Microbiology and Biotechnology 18(98): 7855-67, (2014)
IF: 3.34 -
. "Expression, Purification, and Kinetic Analysis of PTP Domains", pp 39- 66, Protein Tyrosine Phosphatases, Rafael Pulido, (2016).
ISBN: 978-1-4939-3744-8
Grants
“Reconstruction of Ancestor of Receptor Protein Tyrosine Phosphatase Catalytic”
2011-2016
Acronym: PN-II-ID-PCE-2011-3-0743
Budget: 1499990
Project director: Stefan Szedlacsek
Synthesis of the catalytic domain of ancestral PTP and its characterization both in vitro and in vivo.