Romanian Academy
Florentina Pena, PhD
Group: Molecular Cell Biology
Department: Molecular Cell BiologyResearcher
Research interests: protein folding, endoplasmic reticulum stress, hypoxia
Biography
PhD (2006), University of Bucharest
postdoctoral studies (2006-2008) - Utrecht University, Ineke Braakman group, the Netherlands
since 2009 researcher at the Institute of Biochemistry, Stefana's Petrescu laboratory
Grants received as PI:
1) "Cellular mechanisms associated with endoplasmic reticulum in hypoxia. Implications for biomedical research. ". 2010, UEFISCDI, (PN-II-RU-TE-2010-0048)
2) "A robust platform for the discovery of anti-diabetic compounds". 2017, UEFISCDI, (PN-III-P2-2.1-PED-2016-1660)
postdoctoral studies (2006-2008) - Utrecht University, Ineke Braakman group, the Netherlands
since 2009 researcher at the Institute of Biochemistry, Stefana's Petrescu laboratory
Grants received as PI:
1) "Cellular mechanisms associated with endoplasmic reticulum in hypoxia. Implications for biomedical research. ". 2010, UEFISCDI, (PN-II-RU-TE-2010-0048)
2) "A robust platform for the discovery of anti-diabetic compounds". 2017, UEFISCDI, (PN-III-P2-2.1-PED-2016-1660)
Papers
- . Novel luciferase-based GLP-1 reporter assay reveals naturally-occurring secretagogues. British journal of pharmacology, 2022.IF=8.74
Grants
Platforma robusta pentru descoperirea de medicamente anti-diabetice
2016-2019
Acronym: PLATFORMDIAB
Project director: Florentina Pena
Societatea contemporana se afla in mijlocul unei epidemii globale de diabet zaharat tip 2. Aceasta boala este caracterizata de concentratii patologic crescute de glucoza in sangele pacientilor datorita productiei, secretiei si utilizarii inadecvate a insulinei - hormonul principal care regleaza concentratia de glucoza serica. Ne propunem sa generam linii reporter stabile ce pot fi utilizate pentru cuantificarea insulinei secretate.