Laura-Georgiana Manica, PhD Student

Laura-Georgiana Manica
Group: Molecular Cell Biology
Department: Molecular Cell Biology

PhD Student


2016 - present: Ph.D. Student at Institute of Biochemistry of the Romanian Academy; 2016 - 2019: Resident Pharmacist in Pharmaceutical Laboratory at Emercency University Hospital Bucharest; 2011 - 2016: M.Sc. and B.Sc. in Pharmacy at Faculty of Pharmacy, University of Medicine and Pharmacy of Targu-Mures.




High-throughput screening platform for small-molecules with anti-inflammatory potential 2020-2022
Acronym: HTS-IL-1β
Budget: 600.000 RON
Project director: Marioara Chiritoiu-Butnaru

This project aims to develop a sensitive high-throughput screening platform by generating an endogenously tagged interleukin-1β reporter cell line by CRISPR-Cas9 technology, able to monitor stimulated IL-1β secretion with the purpose to identify new chemical compounds with anti-inflammatory activity that will be validated in primary macrophages and a mouse model for sepsis.