Mihaela Trif, PhD

Mihaela Trif
Group: Ligand-Receptor Interactions
Department: Ligand-Receptor Interactions

Senior Scientific Researcher

Research interests: Scientific competence in : Technology of lipidic nanostructures (designing of biocompatible and efficient lipidic nanostructures suitable for the therapy of the inflammatory diseases); biocompatibility studies using different cells in culture; liposome interaction with immunocompetent cells; cellular response investigation during inflammatory process; investigation on the biodistribution and the mechanisms involved in the interaction between different liposome system and cell types, through in vitro and in vivo studies; identification of the liposome target. Principal subjects/occupational skills covered: Liposomes as controlled drug delivery system during inflammatory process - competence in: technology of lipidic nanostructures ; cell culture techniques ; biotoxicity studies -biochemistry, cell biology, immunochemistry techniques.


-BS in Biology/ Biochemistry Section; MSc in Enzymology/ Faculty of Biology, University of Bucharest (1979); -PhD in Biology, Biochemistry field - disertation title „Liposome as carriers for active principle” / Institute of Biochemistry, Romanian Academy (1994). Research stages - University of London, The school of Pharmacy, Centre for drug Delivery Research, UK (Royal Society grant (1992) ; - Martin –Luther University, Faculty of Medicine, Halle, Germany (1994-1995), DAAD-NATO fellowship - Université des Sciences et Technologies de Lille, France. Program International de cooperation scientific (PICS –CNRS) (1994-1996 - University of Glasgow, Dept. of Immunology , Glasgow, UK, (1998 , 1999, 2001, 2003 –3 month/year); Royal Society short term grants; Wellcome Trust grant (ref. 065435/Z/01/Z/2001) Collaborations established with partners involved in national and international cooperation: -2011-2016- coordinator of international grant-PI- ( Subaward Nr 61369 with LSU Ag Center, Louisiana, USA) in the frame of - USDA NIFA Grant 2011-6702; - 2006-2008- coordinator of complex grant with ANCS- CEEX 57/2006, NANOCONTER , with 5 partners, (IOB; INSB; University of Bucharest ; IMT- Bucharest; ICECHIM- www.biochim.ro/ib/ceex.php - 1990-2011- Coordinator of more than 20 national grants (Romanian Academy, Romanian Ministry of Research, Romanian Medical Academy, Romanian Agency of Research-ANCS); -Honorary Research Fellow – University of Glasgow – 1 oct. 1999 – 30 sept. 2000 -Included in ”Who’s Who Medical in Romania” 2006 -Teaching activity: PhD thesis evaluator ; Advisor of BS and MS training in biochemistry, nanoscience and nanotechnology


  • Icriverzi M, Dinca V, Moisei M, Evans RW, Trif M, Roseanu AIcriverzi M et al . "Lactoferrin in Bone Tissue Regeneration", Current medicinal chemistry 12(16), (2019)
    IF: 3.89
  • Moisei Magdalena, Craciunescu Oana, Moldovan Lucia, Roseanu Anca, Trif MihaelaMoisei Magdalena et al . "Lipid Nanostructures Containing Atorvastatin Decrease Lipopolysaccharide-Induced Inflammation in Macrophages", (Journal of Nanoscience and Nanotechnology), (2017)
  • Trif M and Craciunescu O. "Liposomes as Delivery System of Chondroitin Sulfate to the Arthritic Joint by Intra-articular Administration", Austin Arthritis 1(3): 1011, (2016)
  • Trif M, Florian PE, Roseanu A, Moisei M, Craciunescu O, Astete CE, Sabliov CMTrif M et al . "Cytotoxicity and intracellular fate of PLGA and chitosan-coated PLGA nanoparticles in Madin-Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells", Journal of biomedical materials research. Part A 103(11): 3599-611, (2015)
    IF: 3.26
  • Craciunescu O, Moldovan L, Moisei M, Trif MCraciunescu O et al . "Liposomal formulation of chondroitin sulfate enhances its antioxidant and anti-inflammatory potential in L929 fibroblast cell line", Journal of liposome research 23(2): 145-53, (2013)
  • Roseanu A, Florian PE, Moisei M, Sima LE, Evans RW, Trif MRoseanu A et al . "Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells", Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 23(3): 485-92, (2010)
  • Trif M, Roseanu A, Brock JH, Brewer JMTrif M et al . "Designing lipid nanostructures for local delivery of biologically active macromolecules", Journal of liposome research 17(3-4): 237-48, (2007)
    AI: 0.30
  • Trif M, Guillen C, Vaughan DM, Telfer JM, Brewer JM, Roseanu A, Brock JHTrif M et al . "Liposomes as possible carriers for lactoferrin in the local treatment of inflammatory diseases", Experimental biology and medicine (Maywood, N.J.) 226(6): 559-64, (2001)
View all papers


No grants.