Paula Florian, Dr.
Group: Ligand-Receptor Interactions
Department: Ligand-Receptor InteractionsResearch Scientist
Research interests: biochemistry
cell biology
lactoferrin
virology
Biography
Faculty of Biochemistry
Papers
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. "Dynamics of serum cross-neutralization capacity against SARS-CoV-2 Delta variant in convalescent COVID-19 patients", Journal of medical virology 96(2): e29448, (2024)
doi: 10.1002/jmv.29448
IF: 6.80AI: 1.82 -
. "Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities", Nanoscale Advances, (2024)
doi: 10.1039/D3NA00947E
IF: 4.60AI: 0.86 -
. "Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2 Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface", Nanomaterials 13(1): 64, (2023)
IF: 5.72AI: 0.70 -
. "Synthesis and Anti-Melanoma Activity of L-Cysteine-Coated Iron Oxide Nanoparticles Loaded with Doxorubicin", Nanomaterials 13(4): 621-642, (2023)
IF: 5.72AI: 0.70 -
. "Titanium Surface Nanostructuring by Picosecond Laser Irradiation for Surface Improvement of Dental Abutments", JLMN-Journal of Laser Micro/Nanoengineering 18(3): 127-132, (2023)
doi: 10.2961/jlmn.2023.03.2003
IF: 1.10AI: 0.15 -
. "New Poly(N-isopropylacrylamide-butylacrylate) Copolymer Biointerfaces and Their Characteristic Influence on Cell Behavior In Vitro", International journal of molecular sciences 23(7), (2022)
IF: 5.92AI: 1.12 -
. "Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices", Polymers 13(9), (2021)
IF: 4.33AI: 0.90 -
. "Salecan-Clay Based Polymer Nanocomposites for Chemotherapeutic Drug Delivery Systems; Characterization and In Vitro Biocompatibility Studies", Materials (Basel, Switzerland) 13(23), (2020)
IF: 3.62AI: 0.80 -
. "Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications", Materials (Basel, Switzerland) 12(16), (2019)
IF: 2.97 -
. "Lithium-Doped Biological-Derived Hydroxyapatite Coatings Sustain In Vitro Differentiation of Human Primary Mesenchymal Stem Cells to Osteoblasts", Coatings 12(9), (2019)
IF: 2.35 -
. "Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic implants", Applied Surface Science 439: 724-735, (2018)
IF: 5.15AI: 0.60 -
. "Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic implants", (Applied Surface Science), (2018)
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. "Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release", Nanomaterials (Basel, Switzerland) 7(12), (2017)
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. "Optimization of Recombinant Lipoic Acid Ligase Expression from Bacterial Cells", (Romanian Biotechnological Letters), (2016)
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. "Recent advances in human viruses imaging studies", Journal of basic microbiology 56(6): 591-607, (2016)
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. "Cytotoxicity and intracellular fate of PLGA and chitosan-coated PLGA nanoparticles in Madin-Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells", Journal of biomedical materials research. Part A 103(11): 3599-611, (2015)
IF: 3.26 -
. "MAPLE-based method to obtain biodegradable hybrid polymeric thin films with embedded antitumoral agents", Biomedical microdevices 16(1): 11-21, (2014)
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. "Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment", Journal of virology 87(11): 6415-27, (2013)
IF: 4.65AI: 1.50 -
. "Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide", Journal of medical virology 85(5): 780-8, (2013)
IF: 2.22AI: 0.70 -
. "Endocytosis and trafficking of human lactoferrin in macrophage-like human THP-1 cells (1)", Biochemistry and cell biology = Biochimie et biologie cellulaire 90(3): 449-55, (2012)
IF: 2.92 -
. "Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells", Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 23(3): 485-92, (2010)
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. "Multifunctional thin films of lactoferrin for biochemical use deposited by MAPLE technique", Applied Surface Science 255(10): 5491-5495, (2009)
AI: 0.60
Grants
Human lactoferrin-derived peptides with broad spectrum antiviral activity
2017-2018
Acronym: PEPTIVIR
Budget: 133.300 Euro
Project director: Catalin Lazar
Lactoferrin (Lf), an immunomodulatory glycoprotein was shown to interfere with the life-cycles of many viruses. Our group has rationally designed and characterized the anti-HBV activity of an Lf-derived peptide containing one of the cationic clusters. This project proved the concept that the development of non-toxic, small Lf-derived molecule(s) with a broad-spectrum anti-viral activity may constitute a valuable, cheaper alternative to the current standard of care.