Paula Florian, Dr.

Paula Florian
Group: Ligand-Receptor Interactions
Department: Ligand-Receptor Interactions

Research Scientist

Research interests: biochemistry cell biology lactoferrin virology


Faculty of Biochemistry


  • Nedelcu I, Florian P, Ion D, Militaru E, Damalan A, Popescu CI, Hristea ANedelcu I et al . "Dynamics of serum cross-neutralization capacity against SARS-CoV-2 Delta variant in convalescent COVID-19 patients", Journal of medical virology 96(2): e29448, (2024)
    doi: 10.1002/jmv.29448
    IF: 12.70AI: 1.82
  • Madalina Icriverzi, Paula Ecaterina Florian, Anca Bonciu, Luminita Nicoleta Dumitrescu, Antoniu Moldovan, Diana Pelinescu, Robertina Ionescu, Ionela Avram, Cristian VA Munteanu, Livia Elena Sima, Valentina Dinca, Laurentiu Rusen, Anca RoseanuMadalina Icriverzi et al . "Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities", Nanoscale Advances, (2024)
    doi: 10.1039/D3NA00947E
    IF: 4.70AI: 0.86
  • Nistorescu S, Icriverzi M, Florian PE, Bonciu A, Marascu V, Dumitrescu N, Gradisteanu Pircalabioru G, Rusen L, Mocanu A, Roseanu A, Cimpean A, Grama F, Dinca V, Cristian DANistorescu S et al . "Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2 Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface", Nanomaterials 13(1): 64, (2023)
    IF: 5.72AI: 0.70
  • Toderascu LI, Sima LE, Orobeti S, Florian PE, Icriverzi M, Maraloiu V-A, Comanescu C, Iacob N, Kuncser V, Antohe I, Popescu-Pelin G, Stanciu G, Ionita P, Mihailescu CN, Socol GToderascu LI et al . "Synthesis and Anti-Melanoma Activity of L-Cysteine-Coated Iron Oxide Nanoparticles Loaded with Doxorubicin", Nanomaterials 13(4): 621-642, (2023)
    IF: 5.72AI: 0.70
  • Jipa F, Florian P, Icriverzi M, Popescu-Pelin G Budei D, Axente E, Sugioka K, Sima FJipa F et al . "Titanium Surface Nanostructuring by Picosecond Laser Irradiation for Surface Improvement of Dental Abutments", JLMN-Journal of Laser Micro/Nanoengineering 18(3): 127-132, (2023)
    doi: 10.2961/jlmn.2023.03.2003
    IF: 1.10AI: 0.15
  • Dumitrescu NL, Icriverzi M, Bonciu A, Florian P, Moldovan A, Roseanu A, Rusen L, Dinca V, Grama FDumitrescu NL et al . "New Poly(N-isopropylacrylamide-butylacrylate) Copolymer Biointerfaces and Their Characteristic Influence on Cell Behavior In Vitro", International journal of molecular sciences 23(7), (2022)
    IF: 5.92AI: 1.12
  • Gherasim O, Popescu-Pelin G, Florian P, Icriverzi M, Roseanu A, Mitran V, Cimpean A, Socol GGherasim O et al . "Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices", Polymers 13(9), (2021)
    IF: 4.33AI: 0.90
  • Florian PE, Icriverzi M, Ninciuleanu CM, Alexandrescu E, Trica B, Preda S, Ianchis R, Roseanu AFlorian PE et al . "Salecan-Clay Based Polymer Nanocomposites for Chemotherapeutic Drug Delivery Systems; Characterization and In Vitro Biocompatibility Studies", Materials (Basel, Switzerland) 13(23), (2020)
    IF: 3.62AI: 0.80
  • Grumezescu V, Gherasim O, Negut I, Banita S, Holban AM, Florian P, Icriverzi M, Socol GGrumezescu V et al . "Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications", Materials (Basel, Switzerland) 12(16), (2019)
    IF: 2.97
  • Florian P, Duta L, Grumezescu V, Popescu-Pelin G, Popescu A, Oktar F, Evans R, Roseanu Constantinescu A.Florian P et al . "Lithium-Doped Biological-Derived Hydroxyapatite Coatings Sustain In Vitro Differentiation of Human Primary Mesenchymal Stem Cells to Osteoblasts", Coatings 12(9), (2019)
    IF: 2.35
  • Popescu A C, Florian P E, Stan G E, Popescu-Pelin G, Zgura I, Enculescu M, Oktar F N, Trusca R, Sima L E, Roseanu A, Duta LPopescu A C et al . "Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic implants", Applied Surface Science 439: 724-735, (2018)
    IF: 5.15AI: 0.60
  • Popescu A., Florian P., Stan G., Popescu-Pelin G., Zgura I., Enculescu M., Oktar F., Trusca R., Sima L., Roseanu APopescu A. et al . "Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic implants", (Applied Surface Science), (2018)
  • Ianchis R, Ninciuleanu CM, Gifu IC, Alexandrescu E, Somoghi R, Gabor AR, Preda S, Nistor CL, Nitu S, Petcu C, Icriverzi M, Florian PE, Roseanu AMIanchis R et al . "Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release", Nanomaterials (Basel, Switzerland) 7(12), (2017)
  • Paula Ecaterina Florian, Georgiana Petrareanu, Simona Maria Ruţă, Anca RoseanuPaula Ecaterina Florian et al . "Optimization of Recombinant Lipoic Acid Ligase Expression from Bacterial Cells", (Romanian Biotechnological Letters), (2016)
  • Florian PE, Rouillé Y, Ruta S, Nichita N, Roseanu AFlorian PE et al . "Recent advances in human viruses imaging studies", Journal of basic microbiology 56(6): 591-607, (2016)
  • Trif M, Florian PE, Roseanu A, Moisei M, Craciunescu O, Astete CE, Sabliov CMTrif M et al . "Cytotoxicity and intracellular fate of PLGA and chitosan-coated PLGA nanoparticles in Madin-Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells", Journal of biomedical materials research. Part A 103(11): 3599-611, (2015)
    IF: 3.26
  • Dinca V, Florian PE, Sima LE, Rusen L, Constantinescu C, Evans RW, Dinescu M, Roseanu ADinca V et al . "MAPLE-based method to obtain biodegradable hybrid polymeric thin films with embedded antitumoral agents", Biomedical microdevices 16(1): 11-21, (2014)
  • Macovei A, Petrareanu C, Lazar C, Florian P, Branza-Nichita NMacovei A et al . "Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment", Journal of virology 87(11): 6415-27, (2013)
    IF: 4.65AI: 1.50
  • Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita NFlorian PE et al . "Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide", Journal of medical virology 85(5): 780-8, (2013)
    IF: 2.22AI: 0.70
  • Florian P, Macovei A, Sima L, Nichita N, Mattsby-Baltzer I, Roseanu AFlorian P et al . "Endocytosis and trafficking of human lactoferrin in macrophage-like human THP-1 cells (1)", Biochemistry and cell biology = Biochimie et biologie cellulaire 90(3): 449-55, (2012)
    IF: 2.92
  • Roseanu A, Florian PE, Moisei M, Sima LE, Evans RW, Trif MRoseanu A et al . "Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells", Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 23(3): 485-92, (2010)
  • Constantinescu C, Palla-Papavlu A, Rotaru A, Florian P, Chelu F, Icriverzi M, Nedelcea A, Dinca V, Roseanu A, Dinescu M.Constantinescu C et al . "Multifunctional thin films of lactoferrin for biochemical use deposited by MAPLE technique", Applied Surface Science 255(10): 5491-5495, (2009)
    AI: 0.60
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Human lactoferrin-derived peptides with broad spectrum antiviral activity 2017-2018
Budget: 133.300 Euro
Project director: Catalin Lazar

Lactoferrin (Lf), an immunomodulatory glycoprotein was shown to interfere with the life-cycles of many viruses. Our group has rationally designed and characterized the anti-HBV activity of an Lf-derived peptide containing one of the cationic clusters. This project proved the concept that the development of non-toxic, small Lf-derived molecule(s) with a broad-spectrum anti-viral activity may constitute a valuable, cheaper alternative to the current standard of care.