Catalin Lazar, PhD

Biography
Catalin Lazar is a researcher in the Institute of Biochemistry of the Romanian Academy. Catalin is currently working in Viral Glycoproteins in the Viral Glycoproteins.
Papers
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. "N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis", Cells 6(9), (2020)
IF: 5.60 -
. "Production of Chimeric Hepatitis B Virus Surface Antigens in Mammalian Cells", Methods in Molecular Biology, Blaine Pfeifer and Andrew Hill (eds.). Springer Science. 2183(Vaccine Delivery Technology: Methods and Protocols), (2020)
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. "Oral administration of a chimeric Hepatitis B Virus S/preS1 antigen produced in lettuce triggers infection neutralizing antibodies in mice", Vaccine 36(38): 5789-5795, (2018)
IF: 3.27 -
. "Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination", Plant biotechnology journal 15(12): 1611-1621, (2017)
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. "Novel function of the endoplasmic reticulum degradation-enhancing α-mannosidase-like proteins in the human hepatitis B virus life cycle, mediated by the middle envelope protein", Cellular microbiology 19(2), (2017)
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. "Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide", Journal of medical virology 85(5): 780-8, (2013)
IF: 2.22AI: 0.70 -
. "Activation of ERAD pathway by human hepatitis B virus modulates viral and subviral particle production", PloS one 7(3): e34169, (2012)
IF: 3.73AI: 1.50 -
. "Antiviral activity of lactoferrin against bovine viral diarrhea virus", Romanian Jornal of Biochemistry(42): 21-29, (2005)
Grants
EEA Grants (2014-2021): Next Generation Viral Hepatitis B and C vaccine development in plants and algae using advanced biotechnological tools; ‘’Dezvoltare de vaccinuri de ultima generatie anti Virusurile Hepatice B si C in plante si alge, utilizand metode biotehnologice avansate’’
2019-2023
Acronym: SmartVac
Budget: 1.500.000 EUR
Project director: Norica Nichita
We aim to produce high yields of novel HBV/HCV antigens with superior immunogenic properties in plants and mammalian cells, based on innovative molecular design and establish in premiere an advanced biotechnological platform for production of best vaccine candidates antigens in algae.
Molecular mechanisms of hepatitis B virus egress
2018-2020
Acronym: HBVEGRESS
Project director: Catalin Lazar