Radiolabelling of affibody for tumor diagnostic and theranostic application in the nuclear medicine

Radiolabelling of affibody for tumor diagnostic and theranostic application in the nuclear medicine 2022-2024
Acronym: Bilateral agreement no.2886/15.09.2021 Romanian Academy- Hungarian Academy of Sciences
Project director: Stefan Szedlacsek
Bilateral projects
External website: full link

The project is agreed as a joint collaboration among IBAR, ATOMKI and UD, the latter being a cost free participant. There are two main directions envisaged by the proposed project: - receptors mapping and therapy, using an affibody against HER2 receptors, combined with an adequate radioisotope. In this respect, the specific objectives are: a) expression and purification of affibodies; b) establishing labelling procedures; c) ex vivo and/or in vivo testing of optimal compounds.

Stefan Szedlacsek, Dr.
Stefan Szedlacsek, Dr.

Head of Department

Prof. Dr. Stefan Szedlacsek is the Head of the Enzymology Department at the Institute of Biochemistry of the Romanian Academy. He holds a PhD degree in Biotechnology from Polytechnical University of Bucharest as well as a MSc in Organic Synthesis (Polytechnical University, Bucharest) and MSc in Mathematics (University of Bucharest). As a visiting scientist, he performed research in the field of cholesterol metabolism at the University of Illinois at Urbana-Champaign (USA), where he succeeded to evidence a new pathway in the metabolism of oxysterols.  He is an “Alexander von Humboldt” fellow and worked in Germany, in the Institute of Biochem More...

Adina-Gabriela Puiu, PhD Student
Adina-Gabriela Puiu, PhD Student

Research Assistant

Adina has a Bachelor's degree in Biology and a Master's degree in Applied Genetics and Biotechnology from the Faculty of Biology, University of Bucharest. She is a PhD student and Research Assistant at the Institute of Bio More...

Andra-Elena Cosoreanu
Andra-Elena Cosoreanu

Andra-Elena Cosoreanu is a researcher in the Institute of Biochemistry of the Romanian Academy. Andra-Elena is currently working in Enzymology in the Enzymology.

Andrei-Mihai Vasilescu, PhD Student
Andrei-Mihai Vasilescu, PhD Student

Research Assistant

Andrei-Mihai Vasilescu is a researcher in the Institute of Biochemistry of the Romanian Academy. Andrei-Mihai is currently working in Enzymology in the Enzymology.

Bica Constantin Catalin, MSc
Bica Constantin Catalin, MSc

Asistent

Bica Constantin Catalin is a researcher in the Institute of Biochemistry of the Romanian Academy. Bica is currently working in Enzymology in the Enzymology.

                                      

 

          

 

 

 

 

 

 

 

 

                                                             

 

 

 

Under construction

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10 may 2023: Seminar IBAR

1. Lecture title: "Labelling anti-HER2-affibodies with 52Mn via pyclen based bifunctional ligands: from ligand to in vivo PET/MR experiments"

-Balazs Varadi, PhD(c), Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Hungary, Institute for Nuclear Research, Debrecen, Hungary.

2. Lecture title: "Designing macrocyclic ligands for biomedical application"

-Professor Gyula Tircso, PhD, Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Hungary.

 

2 september 2024: "Ion Heliade Radulescu Auditorium" Romanian Academy; Frontiers in Biochemistry: Romania-China Collaborative Perspectives

Lecture title: "Rationally-Designed Targeting Agents in Cancer and Neurodegenerative Disorders" - PhD student, Andrei - Mihai Vasilescu

 

Publication:

1. "Mn(II)-based diagnostic agents: from basic research to targeted diagnostic procedures"; Balázs Váradi, Gergő Zoltán Sajtos, Károly Brezovcsik, Zoltan Szűcs, Stefan Szedlacsek, Gábor Nagy, Gyula Tircso;  Scientia et Securitas 5(2): 253-266, 2024 Nov25 doi: https://doi.org/10.1556/112.2024.00208

2. Editorial: „Molecular targets in oncological and hematological disease management: innovations in precision medicine"; Adrian Bogdan Tigu, Gregory Wiedman, Stefan Eugen Szedlacsek; Frontiers in Pharmacology; 2024 Sep 20 DOI: 10.3389/fphar.2024.1494396