Ioan Valentin Matei, M.D., Ph.D.

Ioan Valentin Matei

Currently this member has a different affiliation

Group: Systems Biology of Aging
Department: Bioinformatics & Structural Biochemistry

Scientific Researcher

Research interests: aging, C.elegans, regenerative medicine, cellular agriculture, stem cell biology, cell therapies


Ioan has a background in regenerative medicine, cell therapies, stem cell biology, diabetes and aging. He has worked in endocrine pancreatic cell differentiation, starting with his Ph.D. at the Nippon Dental University Graduate School at Tokyo, where he studied dental mesenchymal stem cell differentiation into endocrine pancreatic cells and devised an in vitro model of glucotoxicity mitigation, as a recipient of the Japanese Government Monbukagakusho MEXT Scholarship. During his postdoctoral years, he worked at OncoGen Timisoara, and then as part of the Dia-Cure project at Titu Maiorescu University’s Cajal Institute and CEMT Fundeni, headed by Prof. Sarah Ferber of Sheba Medical Center, Tel Aviv University and Orgenesis Ltd, studying the modulation of diabetic liver-to-pancreas transdifferentiation. Ioan currently works in aging research and synthetic biology as part of the Systems Biology of Aging Group, assessing longevity-promoting genetic interventions in C. elegans for corroborating synergistic gene interactions generated through bioinformatic modelling, as well as automating C.elegans lifespan measurements for interventional studies of age-related diseases.


  • Har-Zahav A, Lixandru D, Cheishvili D, Matei IV, Florea IR, Aspritoiu VM, Blus-Kadosh I, Meivar-Levy I, Serban AM, Popescu I, Szyf M, Ferber S, Dima SOHar-Zahav A et al . "The role of DNA demethylation in liver to pancreas transdifferentiation", Stem cell research & therapy 13(1): 476, (2022)
    IF: 8.07
  • Matei IV, Samukange VNC, Bunu G, Toren D, Ghenea S, Tacutu RMatei IV et al . "Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans", Aging 13(17): 21040-21065, (2021)
    IF: 5.60AI: 1.16
  • Iacob R, Herlea V, Savu L, R Florea I, M Ilie V, Terinte-Balcan G, Gherghiceanu M, Uta M, Popa C, Iacob S, V Matei I, Jardan C, Lixandru D, Dima S, Meivar-Levy I, Ferber S, Popescu IIacob R et al . "Phenotypic assessment of liver-derived cell cultures during in vitro expansion", Regenerative medicine 16(1): 33-46, (2021)
    IF: 3.21
  • Matei IV, Meivar-Levy I, Lixandru D, Dima S, Florea IR, Ilie VM, Albulescu R, Popescu I, Ferber SMatei IV et al . "The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation", Regenerative medicine, (2021)
    IF: 2.59
  • Matei IV, Ii H, Yaegaki KMatei IV et al . "Hydrogen sulfide enhances pancreatic β-cell differentiation from human tooth under normal and glucotoxic conditions", Regenerative medicine 12(2): 125-141, (2017)
    IF: 2.99
  • Ionescu-Tirgoviste C, Matei IV, Ivanus B, Falcan AM.Ionescu-Tirgoviste C et al . "Contributions of evolutionary biology to the understanding of cancer", Proceedings of the Romanian Academy Series B 3(14): 183-190, (2012)
  • Gligor R, Zdremtan D, Pilat L, Matei I, Ionescu-Tirgoviste C, Crisnic I.Gligor R et al . "Correlations of visfatin with the lipidic metabolism in diabetic and obese patients", Proceedings of the Romanian Academy Series B 1(14): 37-43, (2012)
  • Ionescu-Tirgoviste C, Matei IV, Gubceac E, Militaru M, Gutu D, Lixandru DIonescu-Tirgoviste C et al . "A cytomorphometric analysis of adipocytes from the omental and abdominal subcutaneous adipose tissue", Proceedings of the Romanian Academy Series B 3(13): 212-236, (2011)
View all papers


Gerontomics: Multi-omics prediction system for prioritization of gerontological interventions 2016-2021
Acronym: Gerontomics
Project director: Robi Tacutu

Starting 02.09.2016, the Institute of Biochemistry of the Romanian Academy is implementing the project “Multi-omics prediction system for prioritization of gerontological interventions”, co-funded through European Fund for Regional Development, in accordance with the funding contract signed by the Ministry of National Education and Scientific Research. The total funding for the project is 8.524.757,50 lei, of which 8.502.557,50 lei represent non-reimbursable funding. The project’s duration is 48 months.

Automated Nematode Screening for Neurodegenerative Diseases 2020-2022
Acronym: ANS-ND
Budget: 600,000 RON
Project director: Robi Tacutu

The project aims to experimentally develop an integrated and automated solution for screening drugs and genetic interventions for neurodegenerative diseases, using the nematode C. elegans and ageing-related data.