Rodica-Aura Badea, Dr.
- . Novel luciferase-based GLP-1 reporter assay reveals naturally-occurring secretagogues. British journal of pharmacology, 2022.IF=8.74
- . Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 1520-4804(ISSN 0022-2623).IF=7.45
- . WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton. Scientific reports, 2018, 8(1):2910.
- . Expression, Purification, and Kinetic Analysis of PTP Domains. Methods in molecular biology (Clifton, N.J.), 2016, 1447:39-66.
Molecular modeling of a set of peptides that can disrupt the GluA2-Cterm complex with STEP (Complex A) or BRAG2 (ComplexB).
The project is agreed as a joint collaboration among IBAR and ATOMKI, UD and IFIN-HH is a cost free participant. There are two main directions envisaged by the proposed project: receptors mapping and therapy, using an affibody against HER2 receptor, combined with an adequate radioisotope. In this respect, the specific objectives are: a) expression and purification of affibodies; b) establish labeling procedures; c) ex vivo and/or in vivo testing of optimal compounds.
Enzymatic characterization of both mEya3 and hEya1 to identify the similarities and differences between these two proteins with relatively low sequence homology.
Synthesis of the catalytic domain of ancestral PTP and its characterization both in vitro and in vivo.