Cristian Munteanu, Dr.

Biography
2019: Research Scientist (CS) III at the Institute of Biochemistry of the Romanian Academy (IBRA)
2016 – 2019: Research Scientist (CS) at the Institute of Biochemistry of the Romanian Academy (IBRA)
2014 – 2016: Research Assistant at IBRA
EDUCATION AND TRAINING
2012 – 2017: Ph.D. in Biology at Institute of Biochemistry of the Romanian
Academy (IBRA) with the thesis title: “Insights into functional
interaction proteomics of endoplasmic reticulum associated
degradation (ERAD) and antigen presentation in melanoma using
mass spectrometry”, Coordinators: Dr. Andrei Jose Petrescu/Dr.
Niculina Mitrea (University of Medicine and Pharmacy Carol Davila,
Bucharest)
2011 – 2014: Resident Pharmacist in Pharmaceutical Laboratory at University of
Medicine and Pharmacy (UMF) Carol Davila, Bucharest, Romania
(Accredited Postgraduate Medical Specialization by the Ministry of
Health from Romania)
2010 – 2012: MSc in Biological Chemistry at Normal Superior School of
Bucharest (NSSB) - IBRA with the thesis title: “Expression and
purification of the antimicrobial peptide Cecropin P1 in Escherichia
Coli”
2005 – 2010: B.Sc. and M.Sc in Pharmacy at UMF Carol Davila (Bucharest,
Romania) with the thesis title: “HPLC and molecular modeling
stability evaluation of inclusion complexes between repaglinide and
beta-cyclodextrin”
Papers
-
. "Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition", Frontiers in molecular biosciences 9: 1064868, (2022)
IF: 6.11AI: 1.33 -
. "A Study on Repositioning Nalidixic Acid via Lanthanide Complexation: Synthesis, Characterization, Cytotoxicity and DNA/Protein Binding Studies", Pharmaceuticals 18(15): 1010, (2022)
IF: 5.20AI: 0.67 -
. "Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry", Molecules 21(27): 7359, (2022)
IF: 4.93AI: 0.67 -
. "Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry", Molecules 13(27): 4056, (2022)
IF: 4.93AI: 0.67 -
. "High-Resolution Tandem Mass Spectrometry Identifies a Particular Ganglioside Pattern in Early Diabetic Kidney Disease of Type 2 Diabetes Mellitus Patients", Molecules (Basel, Switzerland) 27(9), (2022)
IF: 4.93AI: 0.67 -
. "Isolation, characterization, and mode of action of a class III bacteriocin produced by Lactobacillus helveticus 34.9", World J Microbiol Biotechnol .(38): 220, (2022)
IF: 4.25AI: 0.64 -
. "Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats", JOURNAL OF MEDICINAL CHEMISTRY 1520-4804(ISSN 0022-2623), (2021)
IF: 7.45 -
. "Affinity proteomics and deglycoproteomics uncover novel EDEM2 endogenous substrates and an integrative ERAD network", Molecular & cellular proteomics : MCP: 100125, (2021)
IF: 5.91AI: 2.26 -
. "Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo", Cancer biology & therapy: 1-16, (2021)
IF: 4.74 -
. "EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning", Int. J. Mol. Sci. 4(22): 2172, (2021)
IF: 4.56AI: 0.80 -
. "High-resolution mass spectrometry reveals a complex ganglioside pattern and novel polysialylated structures associated with the human motor cortex", European journal of mass spectrometry (Chichester, England): 14690667211040912, (2021)
IF: 0.85 -
. "Dataset of human EDEM2 melanoma cells proteomics, affinity proteomics and deglycoproteomics", Data in brief 39: 107471, (2021)
-
. "Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning", Cellular and molecular neurobiology, (2020)
IF: 3.80 -
. "Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation", International Journal of Molecular Sciences 20(24): 6307, (2019)
IF: 4.18 -
. "Gangliosidome of human anencephaly: A high resolution multistage mass spectrometry study", Biochimie 163: 142-151, (2019)
IF: 3.36 -
. "Secondary compounds in the catalytic hydrogenation of enone and allylic alcohol prostaglandin intermediates: isolation, characterization, and X-ray crystallography", New Journal of Chemistry 43(20): 7582-7599, (2019)
IF: 3.00 -
. "Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry", Advances in experimental medicine and biology 1140: 155-167, (2019)
IF: 2.13 -
. "Human caudate nucleus exhibits a highly complex ganglioside pattern as revealed by high-resolution multistage Orbitrap MS", Journal of Carbohydrate Chemistry 38(9), (2019)
IF: 0.80 -
. "Identification and structural characterization of novel O- and N-glycoforms in the urine of a Schindler disease patient by Orbitrap mass spectrometry", Journal of Mass Spectrometry 50(9): 1044‐1056, (2015)
IF: 2.54AI: 0.70 -
. "COMBINING HETEROLOGOUS BACTERIAL EXPRESSION SYSTEM WITH AFFINITY CHROMATOGRAPHY PURIFICATION TO OBTAIN NATIVE MOUSE TYROSINASE", Farmacia 2(63): 254-261, (2015)
IF: 1.16 -
. "Three-dimensional Modeling and Diversity Analysis Reveals Distinct AVR Recognition Sites and Evolutionary Pathways in Wild and Domesticated Wheat Pm3 R Genes", Molecular Plant Microbe Interactions 27(8): 835-845, (2014)
IF: 3.94AI: 1.30 -
. "Identification of an unusually sulfated tetrasaccharide chondroitin/dermatan motif in mouse brain by combining chip-nanoelectrospray multistage MS2 -MS4 and high resolution MS", Electrophoresis 34(11): 1581‐1592, (2013)
IF: 3.16AI: 0.60
Grants
The overall goal of the current project is to understand the impact of tissue transglutaminase (TG2) targeting in the context of ovarian cancer (OC) tumor microenvironment (TME). Our aproach is aimed at testing the hypothesis that interventions in targeting TG2 in the OC TME will disrupt pro-tumorigenic signaling cross-talk within tumors.
The principal goal of this project is the development of a new class of small molecule inhibitors (SMIs) targeting TG2-FN interaction, which is currently in the phase of lead optimization, translatable to clinical use for prevention of ovarian cancer dissemination, either alone or in combinations.
This project aims to understand the molecular events associated with protein aggregation and how a Golgi located protein along with the UPR pathway modulate this process. Model proteins such as IL-1β and α-synuclein, previously shown to aggregate will be employed for these studies. Achieving the objectives of this project should facilitate the understanding of the signaling pathways and the sequence of events correlating the stress sensing machinery with cytoplasmic proteome instability.